Exploring the Immunomodulatory Potential of Natural Killer T Cells

Grant number: LP140100920 | Funding period: 2015 - 2018

Completed

Abstract

Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.

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D Chennamadhavuni, NA Saavedra-Avila, LJ Carreño, MJ Guberman-Pfeffer, P Arora, T Yongqing, HF Koay, DI Godfrey, S Keshipeddy, SK Richardson, S Sundararaj, JH Lo, X Wen, JA Gascón, W Yuan, J Rossjohn, J Le Nours, SA Porcelli, AR Howell

2018-05-17

Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications fo..

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens

J Le Nours, T Praveena, DG Pellicci, NA Gherardin, FJ Ross, RT Lim, GS Besra, S Keshipeddy, SK Richardson, AR Howell, S Gras, DI Godfrey, J Rossjohn, AP Uldrich

2016-02-15

Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. H..

University of Melbourne Researchers

Dale Godfrey